Bruce Willis in the episode "No Exit"
This is a list of guest stars that appeared on Miami Vice over the course of its five seasons. The series' large repertoire of guest performers was noted at the time of production, but the show has become truly famous since for the large number of guest actors/actresses, unheard of at the time of their casting, who have subsequently gone on to become some of the biggest names in Hollywood.
Please note that this is not an exhaustive list, but rather focusses on guest stars who are well known from other works and/or careers.
Season 1[]
| Episode | Guest | Character | Role |
|---|---|---|---|
| "Brother's Keeper" | Jimmy Smits | Eddie Rivera | James "Sonny" Crockett's ill-fated partner |
| "Brother's Keeper" | Miguel Piñero | Esteban Calderone | Drug lord, head of the Calderone cartel |
| "Brother's Keeper" | Mykelti Williamson | Leon Jefferson | Informant |
| "Brother's Keeper" | Martin Ferrero | Trini DeSoto | Middleman/hitman for Esteban Calderone |
| "Brother's Keeper" | Belinda Montgomery | Caroline Crockett | Crockett's estranged ex-wife |
| "Brother's Keeper" | Bill Smitrovich | Scottie Wheeler | DEA Lieutenant/dirty cop |
| "Heart of Darkness" | Ed O'Neill | Arthur Lawson/Artie Rollins | Undercover FBI agent |
| "Heart of Darkness" | Suzy Amis | Penny McGraw | Pornographic actress |
| "Heart of Darkness" | Julio Oscar Mechoso | Lester Kosko | Metro-Dade electronics expert |
| "Cool Runnin'" | Charlie Barnett | Nugart "Noogie" Lamont | Street informant |
| "Cool Runnin'" | Julio Oscar Mechoso | Lester Kosko | Metro-Dade electronics expert |
| "Calderone's Return (Part I)" | Jim Zubiena | Ludovici Armstrong | Hitman |
| "Calderone's Return (Part I)" | Ron Taylor | Linus Oliver | Drug dealer |
| "Calderone's Return (Part I)" | Belinda Montgomery | Caroline Crockett | Crockett's estranged ex-wife |
| "Calderone's Return (Part II)" | Miguel Piñero | Esteban Calderone | Drug lord, head of the Calderone cartel |
| "One Eyed Jack" | Dennis Farina | Al Lombard | Mobster and bookmaker |
| "One Eyed Jack" | Dan Hedaya | Ben Schroeder | Internal Affairs Detective Sergeant |
| "One Eyed Jack" | Julio Oscar Mechoso | Lester Kosko | Metro-Dade electronics expert |
| "No Exit" | Bruce Willis | Tony Amato | Arms dealer |
| "No Exit" | Coati Mundi | Ramone | Tony Amato's right-hand man |
| "No Exit" | Julio Oscar Mechoso | Lester Kosko | Metro-Dade electronics expert |
| "The Great McCarthy" | Martin Ferrero | Isadore "Izzy" Moreno | Conman and street informant |
| "Glades" | John Pankow | Floyd Higgins | Drug runner |
| "Give a Little, Take a Little" | Burt Young | Lupo Ramirez | Pimp |
| "Give a Little, Take a Little" | Michael Madsen | Sally Alvarado | Drug dealer |
| "Give a Little, Take a Little" | Terry O'Quinn | Richard Cain | Defense lawyer for Sally Alvarado |
| "Milk Run" | Eric Bogosian | Zeke | Angela's boyfriend |
| "Milk Run" | Evan Handler | Louis Martinez | Teen attempting to make quick money smuggling drugs |
| "Milk Run" | Julio Oscar Mechoso | Lester Kosko | Metro-Dade electronics expert |
| "Golden Triangle (Part I)" | Julio Oscar Mechoso | Lester Kosko | Metro-Dade electronics expert |
| "Golden Triangle (Part II)" | John Santucci | Dale Menton | CIA Agent |
| "Golden Triangle (Part II)" | Joan Chen | May Ying | Martin "Marty" Castillo's ex-wife |
| "Golden Triangle (Part II)" | Keye Luke | Lao Li | Drug lord from East Asia |
| "Smuggler's Blues" | Glenn Frey | Jimmy Cole | Drug runner and pilot |
| "Smuggler's Blues" | Coati Mundi | Tucker Smith | Hard-partying drug addict |
| "Golden Triangle (Part II)" | Richard Edson | Wavey Davey | Mechanic for Jimmy Cole |
| "Rites of Passage" | Pam Grier | Valerie Gordon | NYPD Detective, former lover of Ricardo "Rico" Tubbs |
| "Rites of Passage" | John Turturro | David Traynor | Pimp |
| "The Maze" | Jay O. Sanders | Tim Duryea | Metro-Dade Detective |
| "The Maze" | Ving Rhames | Georges | Haitian immigrant |
| "The Maze" | Joe Morton | Jack Davis | Hostage negotiator |
| "Made for Each Other | Martin Ferrero | Isadore "Izzy" Moreno | Conman and street informant |
| "Made for Each Other" | Charlie Barnett | Nugart "Noogie" Lamont | Street informant |
| "The Home Invaders | David Patrick Kelly | Jerry | Home invader |
| "The Home Invaders" | Esai Morales | Pete Romano | Home invader |
| "Nobody Lives Forever" | Kim Griest | Brenda | Crockett's girlfriend |
| "Nobody Lives Forever" | Martin Ferrero | Isadore "Izzy" Moreno | Conman and street informant |
| "Evan" | Al Israel | Guzman | Arms dealer |
| "Lombard" | Dennis Farina | Al Lombard | Mobster and bookmaker |
| "Lombard" | Ned Eisenberg | Frederico Librizzi | Crime boss |
Season 2[]
| Episode | Guest | Character | Role |
|---|---|---|---|
| "The Prodigal Son" | Gene Simmons | Newton Windsor Blade | Drug dealer |
| "The Prodigal Son" | Penn Jillette | Jimmy Borges | Drug distributor and middleman |
| "The Prodigal Son" | Anthony Heald | Rene | NYPD Commander |
| "The Prodigal Son" | Pam Grier | Valerie Gordon | NYPD Detective, former lover of Ricardo "Rico" Tubbs |
| "The Prodigal Son" | Bill Smitrovich | Burr | DEA Miami Commander |
| "The Prodigal Son" | Luis Guzman | Miguel Revilla | Drug Dealer |
| "The Prodigal Son" | Miguel Piñero | Esteban Revilla | Drug lord, head of the Revilla cartel |
| "The Prodigal Son" | Charles S. Dutton | Pearson | NYPD Lieutenant |
| "Whatever Works" | Eartha Kitt | Chata | Santeria priestess |
| "Whatever Works" | Martin Ferrero | Isadore "Izzy" Moreno | Conman and street informant |
| "Whatever Works" | The Power Station | As themselves | Performing in a nightclub |
| "Out Where the Buses Don't Run" | Bruce McGill | Hank Weldon | Ex-Vice Detective |
| "Out Where the Buses Don't Run" | Little Richard | Rev. Marvelle Quinn | Street preacher |
| "Out Where the Buses Don't Run" | David Strathairn | Marty Lang | Ex-partner of Hank Weldon |
| "The Dutch Oven" | Cleavant Derricks | David Jones | Nightclub singer, Trudy Joplin's ex-boyfriend |
| "The Dutch Oven" | David Johansen | As himself | Performer at a party |
| "Buddies" | James Remar | Robbie Cann | James "Sonny" Crockett's friend |
| "Buddies" | Nathan Lane | Morty Price | Nightclub comedian |
| "Buddies" | Frankie Valli | Frank Doss | Mobster |
| "Junk Love" | Miles Davis | Ivory Jones | Pimp |
| "Tale of the Goat" | Clarence Williams III | Legba | Gang leader and voodoo priest |
| "Tale of the Goat" | Mykelti Williamson | Sylvio Romulus | Legba's right-hand man |
| "Bushido" | Dean Stockwell | Jack Gretsky | CIA Agent, good friend of Martin "Marty" Castillo |
| "Bushido" | Marc Macaulay | Czuko | KGB Agent |
| "Bought and Paid For" | Martin Ferrero | Isadore "Izzy" Moreno | Conman and street informant |
| "Bought and Paid For" | El DeBarge | As himself | Performing in a club |
| "Bought and Paid For" | Joaquim de Almeida | Nico Arroyo | Playboy womaniser/rapist |
| "Back in the World" | G. Gordon Liddy | William Maynard | Ex-military drug dealer |
| "Back in the World" | Iman | Dakotah | Prostitute |
| "Phil the Shill" | Phil Collins | Phil Mayhew | Conman/gameshow host |
| "Phil the Shill" | Martin Ferrero | Isadore "Izzy" Moreno | Conman and street informant |
| "Phil the Shill" | Kyra Sedgwick | Sarah MacPhail | Drug dealer's girlfriend |
| "Definitely Miami | Ted Nugent | Charlie Basset | Drug delaer |
| "Yankee Dollar" | Ned Eisenberg | Charlie Glide | Drug dealer/stock broker |
| "Yankee Dollar" | Austin Pendleton | Max Rogo | Charlie Glide's assistant |
| "Yankee Dollar" | Pepe Serna | Zabado | Drug delaer |
| "One Way Ticket" | Jan Hammer | As himself | Musician at a wedding |
| "One Way Ticket" | John Heard | Laurence Thurmond | Lawyer |
| "Little Miss Dangerous | Fiona | Jackie McSeidan | Prostitute and serial killer |
| "Florence Italy" | Danny Sullivan | Danny Tepper | Race car driver |
| "Florence Italy" | The Fat Boys | As themselves | Street gang |
| "French Twist" | Leonard Cohen | Francois Zolan | Interpol agent |
| "The Fix" | Bill Russell | Roger Ferguson | Judge |
| "The Fix" | Harvey Fierstein | Benedict | Lawyer |
| "The Fix" | Michael Richards | Pagone | Racketeer |
| "Payback" | Dan Hedaya | Reuben Reydolfo | Middleman for Mario Fuente |
| "Payback" | Roberto Duran | Jesus Maroto | Convict |
| "Payback" | Frank Zappa | Mario Fuente | Drug lord |
| "Free Verse" | Michael Bay | Unnamed | Henchman |
| "Trust Fund Pirates" | Charlie Barnett | Nugart "Noogie" Lamont | Street informant |
| "Trust Fund Pirates" | Gary Cole | Jackson Crane | Drug runner and pilot |
| "Trust Fund Pirates" | Richard Belzer | Captain Hook | Pirate radio DJ |
| "Sons and Lovers" | John Leguizamo | Orlando Calderone | Son of deceased drug lord Esteban Calderone |
| "Sons and Lovers" | Lee Iacocca | Lido | Parks Commissioner (uncredited) |
Season 3[]
| Episode | Guest | Character | Role |
|---|---|---|---|
| "When Irish Eyes Are Crying" | Liam Neeson | Sean Carroon | IRA terrorist |
| "When Irish Eyes Are Crying" | Martin Ferrero | Isadore "Izzy" Moreno | Conman and street informant |
| "When Irish Eyes Are Crying" | Paul Gleason | Bunny Berrigan | Associate of Sean Carroon |
| "When Irish Eyes Are Crying" | Walter Gotell | Max Klizer | Arms dealer |
| "When Irish Eyes Are Crying" | Jeff Fahey | Eddie Kaye | Arms delaer |
| "Stone's War" | G. Gordon Liddy | William Maynard | Ex-military drug dealer |
| "Killshot" | Fernando Allende | Tico Arriola | Jai Alai player |
| "Walk-Alone" | Martin Ferrero | Isadore "Izzy" Moreno | Conman and street informant |
| "Walk-Alone" | Kevin Conway | Fox | Corrupt prison warden |
| "Walk-Alone" | Laurence Fishburne | Keller | Prison guard |
| "Walk-Alone" | Ron Perlman | John Rugar | Director of Prisons |
| "The Good Collar" | Charles S. Dutton | Ed McCain | Youth worker |
| "The Good Collar" | Jsu Garcia | Ramirez | Undercover Metro-Dade officer |
| "The Good Collar" | John Spencer | Lee Atkins | Metro-Dade Lieutenant |
| "The Good Collar" | Terry Kinney | William Pepin | Assistant State Attorney |
| "Shadow in the Dark" | Ed Lauter | Cahill | Metro-Dade Captain |
| "Shadow in the Dark" | Jack Thibeau | Ray Gilmore | Metro-Dade Lieutenant |
| "El Viejo" | Willie Nelson | Jake Pierson | Ex-Texas Ranger |
| "El Viejo" | Steve Buscemi | Rickles | Middleman |
| "Better Living Through Chemistry" | Martin Ferrero | Isadore "Izzy" Moreno | Conman and street informant |
| "Better Living Through Chemistry" | Rob Nilsson | Wango Mack | Drug dealer |
| "Baby Blues" | Stanley Tucci | Steven DeMarco | Adoptive father of smuggled baby |
| "Streetwise" | Bill Paxton | Vic Romano | Undercover Metro-Dade Detective |
| "Streetwise" | Wesley Snipes | Silk | Pimp |
| "Streetwise" | Deborah J. Adair | Carla Cappoletti | Prostitute, girlfriend of Vic Romano |
| "Streetwise" | Marc Macaulay | Unnamed | Hit driver |
| "Forgive Us Our Debts" | Donna Rice | Mrs. Frankel | Wife of Metro-Dade Vice Detective (uncredited) |
| "Down for the Count (Part I)" | Don King | Don Cash | Boxing promoter |
| "Down for the Count (Part I)" | Pepe Serna | Oswaldo Guzman | Drug dealer and bookmaker |
| "Down for the Count (Part I)" | Mark Breland | Bobby Sykes | Boxer |
| "Down for the Count (Part I)" | Randall "Tex" Cobb | Moon | Bobby Sykes' manger and coach |
| "Down for the Count (Part II)" | Pepe Serna | Oswaldo Guzman | Drug dealer and bookmaker |
| "Down for the Count (Part II)" | Robert Pastorelli | Vespa | Mobster working for Alfredo Giulinni |
| "Down for the Count (Part II)" | Joe Dallesandro | Alfredo Giulinni | Mafia don |
| "Cuba Libre" | Willie Colon | Armando Rojas | Drug dealer |
| "Cuba Libre" | Ismael "East" Carlo | Victor Vasquez | Former anti-Castro militant |
| "Duty and Honor" | Haing S. Ngor | Nguyen Van Trahn | South Vietnamese police inspector, friend of Martin "Marty" Castillo |
| "Duty and Honor" | Helena Bonham Carter | Theresa Lyons | Surgeon, James "Sonny" Crockett's girlfriend |
| "Duty and Honor" | Brad Sullivan | Jack Colman | Ex-CIA Agent |
| "Theresa" | Helena Bonham Carter | Theresa Lyons | Surgeon, Crockett's girlfriend |
| "Theresa" | Brad Dourif | Joey Wyatt | Drug dealer |
| "The Afternoon Plane" | John Leguizamo | Orlando Calderone | Son of deceased drug lord Esteban Calderone |
| "The Afternoon Plane" | Vincent D'Onofrio | Leon Wolf | Associate of Orlando Calderone |
| "Lend Me an Ear" | Martin Ferrero | Isadore "Izzy" Moreno | Conman and street informant |
| "Red Tape" | Viggo Mortensen | Eddie Trumbull | Metro-Dade Detective |
| "Red Tape" | Annette Bening | Vicky | Justice Department clerk |
| "Red Tape" | Lou Diamond Phillips | Bobby Diaz | Metro-Dade Detective |
| "By Hooker by Crook" | Melanie Griffith | Christine Von Marburg | Businesswoman/madam |
| "By Hooker by Crook" | George Takei | Kenneth Togaru | Money launderer |
| "By Hooker by Crook" | Martin Ferrero | Isadore "Izzy" Moreno | Conman and street informant |
| "By Hooker by Crook" | Vanity | Ali Ferrand | Prostitute |
| "By Hooker by Crook" | Veronica Cartwright | Unnamed | Society Dame |
| "Knock, Knock... Who's There?" | Ian McShane | Esteban Montoya | Drug dealer |
| "Knock, Knock... Who's There?" | Martin Ferrero | Isadore "Izzy" Moreno | Conman and street informant |
| "Viking Bikers from Hell" | Martin Ferrero | Isadore "Izzy" Moreno | Conman and street informant |
| "Viking Bikers from Hell" | John Matuszak | Lascoe | Biker |
| "Viking Bikers from Hell" | Kim Coates | Jack Cragun | Biker |
| "Viking Bikers from Hell" | Sonny Landham | Toad | Biker |
| "Everybody's in Showbiz | Benicio del Toro | Pito | Henchman |
| "Everybody's in Showbiz" | Coati Mundi | Conejo | Theatrical performer |
| "Everybody's in Showbiz" | Charles Keating | Marty Glickburg | Theatrical agent |
| "Heroes of the Revolution" | Jeroen Krabbe | Klaus Herzog | Ex-lover of Gina Calabrese's mother |
Season 4[]
| Episode | Guest | Character | Role |
|---|---|---|---|
| "Contempt of Court" | Stanley Tucci | Frank Mosca | Mobster |
| "Contempt of Court" | Philip Baker Hall | Delaporte | Judge |
| "Contempt of Court" | Meg Foster | Alice Carson | District attorney |
| "Amen... Send Money" | Brian Dennehy | Bill Bob Proverb | Televangelist |
| "Amen... Send Money" | Ben Stiller | Fast Eddie | Conman |
| "Amen... Send Money" | James Tolkan | Mason Mather | Televangelist |
| "Death and the Lady" | Paul Guilfoyle | Milton Glantz | Pornographic film director |
| "Death and the Lady" | Kelly Lynch | Lori Swann | Pornographic actress |
| "Death and the Lady" | Penelope Ann Miller | Jill Ryder | Sister of murder porn star |
| "Death and the Lady" | Marc Macaulay | Brookings | |
| "The Big Thaw" | Alfred Molina | Unnamed | Attorney |
| "The Big Thaw" | Martin Ferrero | Isadore "Izzy" Moreno | Conman and street informant |
| "Child's Play" | Ving Rhames | Walker Monroe | Small-time arms dealer |
| "Child's Play" | Belinda Montgomery | Caroline Crockett | James "Sonny" Crockett's estranged ex-wife |
| "Child's Play" | Isaac Hayes | Holiday | Arms dealer |
| "God's Work" | Esai Morales | Felipe Cruz | Homosexual lawyer |
| "God's Work" | Francesco Quinn | Francesco Cruz | Brother of Felipe Cruz |
| "Missing Hours" | James Brown | Lou DeLong | Ex-R&B legend and believer in extraterrestrial life |
| "Missing Hours" | Martin Ferrero | Isadore "Izzy" Moreno | Conman and street informant |
| "Missing Hours" | Charlie Barnett | Nugart "Noogie" Lamont | Street informant |
| "Missing Hours" | Chris Rock | Carson | Metro-Dade clerk |
| "Like a Hurricane" | Sheena Easton | Caitlin Davies | Pop singer and James "Sonny" Crockett's second wife |
| "Like a Hurricane" | Xander Berkeley | Tommy Lowe | Record producer |
| "Like a Hurricane" | Teller | Ralph Fisher | Defense lawyer |
| "Like a Hurricane" | Jan Hammer | As himself | Wedding musician |
| "The Rising Sun of Death" | Sheena Easton | Caitlin Davies-Crockett | Pop singer and Crockett's second wife |
| "The Rising Sun of Death" | Cary-Hiroyuki Tagawa | Kenji Fujitsu | Former Japanese police officer |
| "The Rising Sun of Death" | R. Lee Ermey | Ernest Haskell | Metro-Dade Sergeant |
| "The Rising Sun of Death" | James Hong | Riochi Tanaka | Yakuza boss |
| "Love at First Sight" | Sheena Easton | Caitlin Davies-Crockett | Pop singer and Crockett's second wife |
| "Love at First Sight" | Iman | Lois Blyth | Serial killer |
| "Love at First Sight" | Lori Petty | Carol | Member of video dating service |
| "Rock and a Hard Place" | Sheena Easton | Caitlin Davies-Crockett | Pop singer and Crockett's second wife |
| "The Cows of October" | Martin Ferrero | Isadore "Izzy" Moreno | Conman and street informant |
| "The Cows of October" | Harry Shearer | Timothy Anderson | FBI Agent |
| "Vote of Confidence | Larry Pine | Tom Pierce | Gubernatorial candidate |
| "Vote of Confidence" | Lucinda Jenney | Annie Pierce | Wife of Tom Pierce |
| "Baseballs of Death" | Michael Des Barres | Shane DuBois | Pimp |
| "Baseballs of Death" | Tony Plana | Ernesto Guerrero | Chilean diplomat and arms smuggler |
| "Baseballs of Death" | Oliver Platt | Speed Stiles | Arms dealer |
| "Indian Wars" | Joseph Turkel | Levec | Drug dealer |
| "Honor Among Thieves?" | Dylan Baker | Edward Jarrell | Metro-Dade Lieutenant |
| "Hell Hath No Fury..." | Don Harvey | Alan Beaks | Paroled rapist |
| "Hell Hath No Fury..." | John Michael Higgins | Murray Phillips | Television host |
| "Badge of Dishonor" | Jsu Garcia | Colon | Corrupt South Beach Detective |
| "Badge of Dishonor" | Julio Oscar Mechoso | Escobar | Drug dealer |
| "Blood & Roses" | Stanley Tucci | Frank Mosca | Mobster |
| "Blood & Roses" | Michael Wincott | Willy Cook | Money launderer |
| "Blood & Roses" | Meg Foster | Alice Carson | District attorney |
| "Blood & Roses" | Frank Stallone | Billy | Henchman |
| "A Bullet for Crockett" | Jesse Borrego | Enrique Morca-Mendez | Drug dealer |
| "A Bullet for Crockett" | Lisa Vidal | Angel Montepina | Girlfriend of Enrique Morca-Mendez |
| "Deliver Us from Evil" | Martin Ferrero | Isadore "Izzy" Moreno | Conman and street informant |
| "Deliver Us from Evil" | Sheena Easton | Caitlin Davies-Crockett | Pop singer and Crockett's second wife |
| "Mirror Image" | Julia Roberts | Polly Wheeler | Art gallery manager |
| "Mirror Image" | Chris Cooper | Jimmy Hagovitch | Corrupt Fort Lauderdale Detective |
| "Mirror Image" | Antonio Fargas | Alejandro Gutierrez | Middleman |
Season 5[]
| Episode | Guest | Character | Role |
|---|---|---|---|
| "Hostile Takeover" | Joe Santos | Oscar Carrera | Drug lord |
| "Hostile Takeover" | Debra Feuer | Celeste | Trophy wife of Oscar Carrera |
| "Hostile Takeover" | Jon Polito | El Gato | Drug lord |
| "Hostile Takeover" | Victor Argo | Emilio Salazar | South American General and drug runner |
| "Hostile Takeover" | Matt Frewer | Cliff King | Middleman |
| "Redemption in Blood" | Debra Feuer | Celeste | Trophy wife of Oscar Carrera |
| "Redemption in Blood" | Jon Polito | El Gato | Drug lord |
| "Redemption in Blood" | Matt Frewer | Cliff King | Middleman |
| "Heart of Night" | Rosalind Chao | May Ying | Martin "Marty" Castillo's ex-wife |
| "Heart of Night" | James Saito | Ma Sek | May Ying's husband |
| "Bad Timing" | Melissa Leo | Kathleen Gilfords | Bartender |
| "Bad Timing" | William O'Leary | Scotty McKenna | Former armed robber |
| "Bad Timing" | Jermaine Stewart | As himself | Performing at a prison |
| "Bad Timing" | Marc Macaulay | Doc Jerry | Former armed robber |
| "Borrasca" | Juan Fernandez | Martillo Borrasca | Drug lord |
| "Borrasca" | Brion James | Edward Reese | Freelance intelligence agent |
| "Asian Cut" | Cary-Hiroyuki Tagawa | Tegoro | Reformed drug dealer |
| "Hard Knocks" | Richard Jenkins | Marvin Goodman | Mobster |
| "Hard Knocks" | Ismael "East" Carlo | Chi Chi | Bookmaker |
| "Fruit of the Poison Tree" | Stephen McHattie | Sam Boyle | Defense lawyer |
| "Fruit of the Poison Tree" | Tony Sirico | Frank Romano | Mobster |
| "Fruit of the Poison Tree" | Amanda Plummer | Lisa Madsen | Defense lawyer |
| "To Have and to Hold | Belinda Montgomery | Caroline Ballard | James "Sonny" Crockett's estranged ex-wife |
| "To Have and to Hold" | Elpidia Carrillo | Maria Pendroza | Mother-in-law of Ramon Pendroza |
| "To Have and to Hold" | Miguel Ferrer | Ramon Pendroza | Drug dealer |
| "Miami Squeeze" | Robert Joy | Sebastian Ross | Drug dealer |
| "Jack of All Trades" | Jesse Borrego | Octavio Escandero | Drug dealer |
| "The Cell Within" | John P. Ryan | Jake Manning | Reformed murderer |
| "The Cell Within" | Maria Pitillo | Anna | Prostitute |
| "The Lost Madonna" | Michael Chiklis | Jeffrey Whitehead | NYPD Detective |
| "The Lost Madonna" | Ned Eisenberg | Sal Castelli | Mobster |
| "The Lost Madonna" | Elizabeth Berridge | Julia Scianti | Art gallery manager |
| "Over the Line" | Martin Ferrero | Isadore "Izzy" Moreno | Conman and street informant |
| "Over the Line" | Tomas Arana | Walter Stevens | Vigilante Metro-Dade Sergeant |
| "Over the Line" | Kevin Corrigan | Jamison | Vigilante Metro-Dade officer |
| "Victims of Circumstance" | Paul Guilfoyle | John Baker | Leader of Neo-Nazi organization |
| "Victims of Circumstance" | John Leguizamo | Angelo Alvarez | Drug delaer |
| "Victims of Circumstance" | Xander Berkeley | Bailey | Metro-Dade Detective |
| "Victims of Circumstance" | Karen Black | Helen Jackson | Daughter of Hans Kozak |
| "Victims of Circumstance" | William Hickey | Hans Kozak | Former Nazi death camp officer |
| "Freefall" | Ian McShane | Manuel Borbon | Central American dictator |
| "Freefall" | Martin Ferrero | Isadore "Izzy" Moreno | Conman and street informant |
| "Freefall" | Elpidia Carrillo | Felicia | Freedom fighter |
| "Freefall" | Robert Beltran | Jimindez | Manuel Borbon's top aide |
| "Fruit of the Poison Tree" | Tony Sirico | Frank Romano | Mobster |
| "World of Trouble" | Dennis Farina | Al Lombard | Mobster and bookmaker |
| "World of Trouble" | Ned Eisenberg | Frederico Librizzi | Crime boss |
| "World of Trouble" | Vincent Schiavelli | Lawrence Fowler | Scientist |
| "World of Trouble" | Marc Macaulay | Johnny Cottman | Henchman |
| "Miracle Man" | Martin Ferrero | Isadore "Izzy" Moreno | Mobster |
| "Leap of Faith" | Laura San Giacomo | Tania Louis | Undercover officer |
| "Leap of Faith" | Jennifer Rubin | Claire | Student |
| "Too Much, Too Late" | Pam Grier | Valerie Gordon | NYPD Detective, former lover of Ricardo "Rico" Tubbs |
| "Too Much, Too Late" | Martin Ferrero | Isadore "Izzy" Moreno | Conman and street informant |
| "Too Much, Too Late" | Malinda Williams | Lynette | Yvonne's daughter |
| "Too Much, Too Late" | C.C.H. Pounder | Yvonne | Drug addict |
Notes[]
- The only guest stars to appear in both the television series and the Miami Vice film are Jay Amor, Marc Macaulay and Mario Ernesto Sanchez (Amor is uncredited).